Smallpox vaccines: targets of protective immunity
نویسندگان
چکیده
منابع مشابه
Developing new smallpox vaccines.
New stockpiles of smallpox vaccine are required as a contingency for protecting civilian and military personnel against deliberate dissemination of smallpox virus by terrorists or unfriendly governments. The smallpox vaccine in the current stockpile consists of a live animal poxvirus (Vaccinia virus [VACV]) that was grown on the skin of calves. Because of potential issues with controlling this ...
متن کاملProtective Immunity in Mice Following Immunization with the Cochleate-Based Subunit Influenza Vaccines
High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...
متن کاملHumoral immunity to smallpox vaccines and monkeypox virus challenge: proteomic assessment and clinical correlations.
Despite the eradication of smallpox, orthopoxviruses (OPV) remain public health concerns. Efforts to develop new therapeutics and vaccines for smallpox continue through their evaluation in animal models despite limited understanding of the specific correlates of protective immunity. Recent monkeypox virus challenge studies have established the black-tailed prairie dog (Cynomys ludovicianus) as ...
متن کاملFrom Jenner to modern smallpox vaccines.
Edward Jenner, born in 1749, grew up in Berkeley, Gloucestershire, and pursued his interest in medicine in London where he became a student and lifelong close friend of John Hunter the anatomist and surgeon. Jenner returned to Gloucestershire in 1772. At that time, smallpox was an infectious scourge affecting mainly children. Most who reached adulthood had been exposed to the disease with a cas...
متن کاملprotective immunity in mice following immunization with the cochleate-based subunit influenza vaccines
high morbidity and mortality of influenza virus infection makes it an important disease world-wide. mouse is a very well-studied animal model for this disease with similar manifestation to human disease. it would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. cell mediated immunity (proliferativ...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2010
ISSN: 0105-2896
DOI: 10.1111/j.1600-065x.2010.00975.x